Appetite suppression
The reduction in hunger and food intake produced by GLP-1 medications, which fades when they are stopped.
Appetite suppression is the dampening of hunger that makes a calorie deficit feel effortless on a GLP-1. It comes from the drug's action on appetite centers in the brain and on gastric emptying. It is not permanent: when the medication clears, hunger signaling returns, often toward baseline or higher, which is the central reason regain happens. Lifestyle tools (protein, fiber, water, sleep) provide milder, durable forms of appetite control to lean on afterward.