Orexigenic signals
Hunger-promoting signals, chiefly ghrelin, that rise after stopping a GLP-1.
Orexigenic means appetite-stimulating. The main orexigenic hormone is ghrelin, produced by the stomach, which rises before meals and signals hunger. A GLP-1 keeps these signals suppressed; stopping the drug releases the brake, and ghrelin rebounds toward baseline or higher. Because counter-regulation is one-sided (hunger signals rise while fullness signals fall and energy expenditure stays low), the body actively defends its previous weight after cessation.