GLP-1 clearance timeline
A free tool that shows how long Ozempic, Wegovy, Mounjaro, Zepbound, and Saxenda stay in your system, based on published elimination half-lives. Enter your last-dose date to see the clearance curve. Educational, not medical advice.
semaglutide has an elimination half-life of about 7 days.
Estimated cleared so far
...
of semaglutide eliminated
Substantially cleared (~97%)
~35 days
after your last dose
Educational only. This visualizes published average half-lives. Real clearance varies by person, dose, and kidney and liver function, and appetite return is not the same as full elimination. It is not medical advice and does not recommend any dose or schedule. Talk to your clinician about stopping or changing a medication.
As the drug clears, GLP-Done helps you hold the line.
Questions about this tool
How long does Ozempic or Wegovy stay in your system?
Semaglutide (Ozempic, Wegovy) has an elimination half-life of about 7 days, so it takes roughly 5 weeks (about five half-lives) to be substantially cleared, around 97%, after the last dose.
How long does Mounjaro or Zepbound stay in your system?
Tirzepatide (Mounjaro, Zepbound) has a half-life of about 5 days, so it is largely cleared in roughly 25 days. Saxenda (liraglutide) has a much shorter half-life of about 13 hours and clears within a few days.
Does the drug clearing mean my appetite comes straight back?
Not exactly. Full elimination and appetite return are related but not identical. Appetite tends to drift back toward baseline as levels fall, which is why the weeks after stopping matter most. This tool is educational and not medical advice.